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Description
CD163 Recombinant Rabbit mAb,PBS Only(SDT-222-171)Product Specification Host Rabbit Antigen CD163 Synonyms M130, Hemoglobin scavenger receptor Immunogen Synthetic Peptide Location Secreted, Cell membrane Accession Q86VB7 Clone Number SDT 222 171 Antibody Type Recombinant mAb Isotype IgG Application IHC P, FCM, IF Reactivity Hu Purification Protein A Concentration 1 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS Stability & Storage 12 months from date of receipt
Product Specification
| Host | Rabbit |
| Antigen | CD163 |
| Synonyms | M130, Hemoglobin scavenger receptor |
| Immunogen | Synthetic Peptide |
| Location | Secreted, Cell membrane |
| Accession | Q86VB7 |
| Clone Number | SDT-222-171 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | IHC-P, FCM, IF |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS |
| Stability & Storage | 12 months from date of receipt / reconstitution, 4 °C as supplied |
Dilution
| application | dilution | species |
| IHC | 1:500 | |
| IF | 1:200 | |
| FCM | 1:50 |
Background
CD163 is a monocyte/macrophage specific marker expressed predominantly on cells which possess strong anti-inflammatory potential. The expression of CD163 is strongly induced by anti-inflammatory mediators such as glucocorticoids and interleukin-10, while being inhibited by pro-inflammatory mediators such as interferon-gamma. CD163-expressing mononuclear phagocytes, as well as soluble CD163, may both take part in downregulating an inflammatory response [PubMed: 22038213].
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Exchange/Return Notes
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4.6 ★★★★★
Based on 359 reviews
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Product Reviews
★★★★★ 1
My little buddy loves it! (Loves it no more)
I ordered this in advance of the arrival of my 11 wk old Corgi pup. Not knowing what kind of a chewer I was getting, I wanted something that squeaked but did not have too many extremities to rip and tear at. I also didn't want too much stuffing to end up all over my house and in my buddy's tummy. It is soft and well constructed. I like that the snake is compartmentalized so that if one segment is breached, the others are not.
As it turned out, at this time, my pup is not a violent ripper (except for with paper and cardboard). After a week of testing, it is his favorite toy. It took him about two days to figure out how to squeak it and boy does he love it. It is the only toy he will haul around, which is hilarious because its bigger than he is. It is also the only toy that he will play fetch with. I'm also working on "leave it" with the with him.
Nemo chews a lot, but hasn't shown much interest in ripping at his toys, so after a week (if it were washed) it could probably pass as new. I also try to switch him over to a bone or rubber toy when he starts getting really excited. I am weary since my last dog was a lab who would shred her toys in seconds.
Nemo was ripping at the tag (something about paper) so I cut that off to prevent a seem getting opened up. I'm surprised that the tongue is still intact. The tongue and eyes are weak links and Nemo does like to chew on them.
Overall, I'm very pleased with this toy. My husband was skeptical and thought it a bit ridiculous, but even he has decided it was a good buy.
*Update*
Our original snake lasted 7 months. Nemo loved it. He would carry it around with him and squeak it till my husband and I went insane. He had mastered the rapid fire squeak. It was also the only toy he would reliably fetch. After 7 months my pup had punctured two of the squeakers and the fur was getting threadbare in some place. But overall we were very happy with the product.
Last week we had a guest GSP at our home and he demolished the toy within minutes. Shredded all of the squeakers and the casing. So we were forced to get Nemo a new one. Unfortunately they have since changed the design. There is now a piping that goes all the way around the snake (before it was blind stitched). Nemo has a thing about tags and edges, he works slowly and methodically to nibble them off. Once the piping was compromised, Nemo had easy access to the squeakers. This new version of the toy lasted only a few hours. I am extremely disappointed with the changes made. I have reduced my 5 star review to 1 star and will no longer recommend this product.
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Reviewed in the United States on July 6, 2013
★★★★★ 5
These really are durable and tough!
OMG! I have 2 large dogs. A 90 lb.golden retriever and a 75 lb. black lab mix. They LOVE to chew and every squeaky toy I have bought for them is demolished in less than 2-3 days! Even the KONG brand. I have spend hundreds of dollars on various dog toys, chews, squeaky toys, etc.None of them stood a chance! LOL
So, I saw these "stuffingless durable tough" snakes and decided to give it a try! Why not?
My husband even told me NOT to buy them as they would just be torn apart in days.
The snakes came and each dog got one. I ordered 2 of the same color in red. At first, they weren't quite sure what to do with them
as they are pretty long. Approximately 2 feet. They slowly began to trust that this was indeed a "toy" and began chewing on them and our golden retriever was tossing the snake up in the air and biting down on it as it fell to the ground. I also like the fact that the squeakers are a low volume and not so high pitched squeak!
Well, long story short, they have now had the snakes for 6 days and they are still intact and the dogs absolutely love them!!!!
I am so happy I finally found a dog toy that my dogs don't destroy!!! I will definitely be buying more!!
Lainie
Sammamish, Washington
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Reviewed in the United States on March 23, 2018
★★★★★ 5
A winning toy!
Color: No Stuffing Blue Eel, Color: No Stuffing Blue Eel
This is the best dog toy ever! I have a Cockapoo that is 8 years old but thinks she is 2. She chews up everything so I've gone thru a lot of dog toys. This toy has lasted 6 months - truly record breaking for her. It's become all raggy so time to get a new one. Thank you Nocciola for inventing a quality fun toy that lasts. Photo shows toy after 6 mo. of playing
tug of war!
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Reviewed in the United States on May 17, 2026
★★★★★ 5
Winner of the aggressive chew competition
Color: No Stuffing Blue Eel
I bought several toys for an insane Jack Russell and this is the unlikely winner. It is a softer toy, but it is stitched together nicely and there are various components that distract the dog and keep him busy. First, it can be rolled up and stuck with small but strong Velcro patches, so it’s not just a sitting duck, the dog has to figure out how to unroll it which is fun. Next there are five little pockets on one side that you can put treats inside, which draw attention to the toy and give him another task. He did partially rip some of the flaps on the pockets in his zeal to get the treats. Then there is the squeaker, which he dispatched of in like 4 seconds (somehow without ripping the fabric(?)), then there are all sorts of crinkles and textures on both sides. All of this and the good stitching make it a toy he wants to play with but that he doesn’t annihilate in one day. The hard plastic toys are also good but I feel like I need to watch him carefully for fear that a sharp chunk will come off. The medium chew toys are cool but he’s just not into them. So this wins!
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Reviewed in the United States on July 12, 2025
★★★★★ 5
My dogs favorite toy!
Color: Blue & Yellow Eel Bundle
This is my Jack Chi and Yorkies favorite toys (it helps when they get 5 mini milk bones). It is a tough toy, but not impervious to a Jack Chi determination to remove all squeekiees! Squeekie or not, it's still their favorite toy for tug-a-war.
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Reviewed in the United States on April 7, 2026
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