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Description
SDF-1α/CXCL12 Protein, HumanProduct Specification Species Human Synonyms Stromal cell derived factor 1, SDF 1, hSDF 1, C X C motif chemokine 12, Intercrine reduced in hepatomas (IRH; hIRH), Pre B cell growth stimulating factor (PBSF) Accession P48061 Amino Acid Sequence Lys22 Lys89 Expression System E. coli Molecular Weight 10 kDa (Reducing) Purity 95% by SDS PAGE & HPLC Endotoxin <0. 1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized Powder Storage Buffer
Product Specification
| Species | Human |
| Synonyms | Stromal cell-derived factor 1, SDF-1, hSDF-1, C-X-C motif chemokine 12, Intercrine reduced in hepatomas (IRH; hIRH), Pre-B cell growth-stimulating factor (PBSF) |
| Accession | P48061 |
| Amino Acid Sequence | Lys22-Lys89 |
| Expression System | E.coli |
| Molecular Weight | 10 kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE & HPLC |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 20mM Tris, 800mM NaCl, PH8.0 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | Cells. 2020 Oct 13;9(10):2277. |
Background
Fractalkine (FKN, CX3CL1) is produced in neurons and is a unique chemokine that is initially translated as a transmembrane protein but can be proteolytically processed to generate a soluble chemokine. CX3CL1 signals through its unique receptor, CX3CR1, that is expressed in microglia. Within the CNS, fractalkine acts as a regulator of microglia activation in response to brain injury or inflammation. CX3CL1 has been shown to signal through its sole receptor CX3CR1, which is located on microglial cells within the central nervous system (CNS). Although both the membrane bound and soluble forms of CX3CL1 appear to interact with CX3CR1, they do seem to have different signaling capabilities.
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