B7-H3 Recombinant Rabbit mAb,PBS Only (SDT-249-26)
SKU: 74120511231

B7-H3 Recombinant Rabbit mAb,PBS Only (SDT-249-26)

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Description

B7-H3 Recombinant Rabbit mAb,PBS Only (SDT-249-26)Product Specification Host Rabbit Antigen B7 H3 Synonyms CD276 antigen, 4Ig B7 H3, B7 homolog 3 (B7 H3), Costimulatory molecule, CD276 Immunogen Synthetic Peptide Location Membrane Accession Q5ZPR3 Clone Number SDT 249 26 Antibody Type Recombinant mAb Application WB, IHC P, ICC, IP, IF, ICFCM Reactivity Hu Purification Protein A Concentration 1 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS Stability & Storage 12 months

Product Specification


Host Rabbit
Antigen B7-H3
Synonyms CD276 antigen, 4Ig-B7-H3, B7 homolog 3 (B7-H3), Costimulatory molecule, CD276
Immunogen Synthetic Peptide
Location Membrane
Accession Q5ZPR3
Clone Number SDT-249-26
Antibody Type Recombinant mAb
Application WB, IHC-P, ICC, IP, IF, ICFCM
Reactivity Hu
Purification Protein A
Concentration 1 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS
Stability & Storage

12 months from date of receipt / reconstitution, 4 °C as supplied

Dilution


application dilution species
WB 1:1000
IP 1:50
IHC 1:2000
ICFCM 1:500
ICC 1:500
IF 1:1000

Background

B7-H3 is a 316 amino acid-long type I transmembrane protein, existing in two isoforms determined by its extracellular domain. In humans it consists of one pair (2Ig-B7-H3) or two identical pairs (4Ig-B7-H3) due to exon duplication. B7-H3 mRNA is expressed in most normal tissues. In contrast, B7-H3 protein has a very limited expression on normal tissues because of its post-transcriptional regulation by microRNAs. However, B7-H3 protein is expressed at high frequency on many different cancer types (60% of all cancers). In non-malignant tissues, B7-H3 has a predominantly inhibitory role in adaptive immunity, suppressing T cell activation and proliferation. In malignant tissues, B7-H3 is an immune checkpoint molecule that inhibits tumor antigen-specific immune responses. B7-H3 also possesses non-immunological pro-tumorigenic functions such as promoting migration, invasion, angiogenesis, chemoresistance, epithelial-to-mesenchymal transition, and affecting tumor cell metabolism.

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SKU: 74120511231

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4.6 ★★★★★
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netzien
West Palm Beach, US
★★★★★ 5
Excellent fan, moves a lot of air a long distance, and is very quiet
Color: White, Size: 42 inches
We have the other type of Levoit standing fan which is super quiet and moves air nicely inside a room. But we have one side of the house that gets little air flow in general, so we bought this to try and improve the air flow around the house by directing air from one side to the other. We have been using a Vornado fan for this in the past, but the air flow it produces dissipates too quickly and the damn thing sounds like a small jet engine. So as we had such a great experience with the other Levoit fan we tried this one. It is very expensive, and there are cheaper ones available, however we felt that longer distance airflow and quiet were very important to us. We are not disappointed. This fan is really quiet, on lower settings it is whisper quiet, perfect for moving air and still being able to work, or be in a video call. On the highest setting it does make some noise, air moving quickly produces turbulence, there is no way to avoid it. But the noise level is low, and not very noticeable. However it moves huge amounts of air, an directs it very tightly. It does not dissipate even after 30-40ft. Great for moving air around a house. On the down side, it only has 5 speeds, and it only rotates 90 degrees. The other Levoit fan has more options to control the air flow. It displays the temperature but only when changing the settings. It would be nice to have a button on the remote to display temp, even if just briefly. The auto program has no hysteresis when changing fan speeds, so when the temp hits a point where it is going to change, it keeps speeding up and slowing down every second or two. With that the noise becomes noticeable for a while. A 20 second or so hysteresis delay would solve that issue. On the major up side, it is as quiet as advertised, it blows huge amounts of air, even on the lowest setting it moves enough air to slowly flap paper 50ft away, and you cannot hear it. The remote is good, and there is a little nook to store it in. You can have it set to not display anything, so it stays dark at night, the timer works well, although we find we don't use it. It is very easy to open and clean. In short, even though it cost a premium price it ended up being worth it, and now is in use 24/7. Would definitely by again if we needed another one.
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Reviewed in the United States on September 24, 2025
Y
Verified Purchase
Yairis Ch
Pawtucket, US
★★★★★ 5
“Excellent purchase for summer ☀️❄️”
Color: White, Size: 36 inches, Color: White, Size: 36 inches
I bought this 36-inch Levoit tower fan and it far exceeded my expectations. I love that it has a quiet mode, especially the night mode, because it allows me to sleep peacefully without disturbing noises. It cools the room very well, and the airflow is constant and pleasant. I also like that it has several speeds and modes, which allows me to adjust it according to the day's temperature. What I liked most was the design. I love it! It's a super modern tower fan that doesn't take up much space, so it looks good in any corner of the house. The remote control makes it even more practical, since I can use it without getting up. In short, it's an efficient and practical fan, perfect for everyday use. I definitely recommend it if you're looking for a quiet yet powerful fan.
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Reviewed in the United States on May 26, 2026
D
Verified Purchase
Denny Lawson
Port Orchard, US
★★★★★ 5
Best fan I have ever used.
Color: White, Size: 42 inches Wifi
Easy assembly, simple WiFi and Alexa connection. Extremely quiet operation. Fan speeds and oscillating feature are perfect.
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Reviewed in the United States on May 15, 2026
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Verified Purchase
Lady mays healing
Los Angeles, US
★★★★★ 5
It has many conveniences
Color: White, Size: 42 inches, Color: White, Size: 42 inches
I like that it detects temperature and determines what fan speed it should be on to control temperature in the room. Its made a notable difference in my warmest room of the house this summer. Its nice and quiet. You can also adjust the blades up or down if you want to redirect the air flow much like in a vehicle. I got the taller fan for the bigger living space i have and it’s comfortable. I feel the air right away. It’s bot like a pedestal fan. This is much more giving to the entire body rather than just the face. It’s also not as intrusive as a pedestal fan. It fits in smaller spaces. It doesn’t block the view like a pedestal fan
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Reviewed in the United States on July 22, 2025
M
Verified Purchase
Mary Burcham
Phoenix, US
★★★★★ 5
Liked this so much that I purchased a second one for another room
Color: White, Size: 36 inches
I liked this fan so much that I purchased a second one for another room. Works well, has 5 different speeds, several functions and setting. Has a remote control and a space on the fan that holds the remote. I was initially torn between this fan and another brand, but chose this one because it can be easily taken apart for cleaning. Also it is a very good value for the cost. It is not silent, but it is not loud at all. The fan is very sturdy and easy to assemble. The only assembly is a giant plastic nut on the bottom that holds the stand in place. IMO if you choose this fan, you will not be disappointed.
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Reviewed in the United States on May 20, 2026

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