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Description
LDL receptor Recombinant Rabbit mAb (SDT-057-57)Product Specification Host Rabbit Antigen LDL Receptor Synonyms Low density lipoprotein receptor, LDLR Immunogen Synthetic Peptide Location Golgi Apparatus, Lysosome, Endosome, Plasma Membrane Accession P01130 Clone Number SDT 057 57 Antibody Type Rabbit mAb Application WB, IHC P Reactivity Hu, Ms, Rt Predicted Reactivity Bv, Rb Purification Protein A Concentration 0. 25mg ml Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05%BSA, 0.
Product Specification
| Host | Rabbit |
| Antigen | LDL Receptor |
| Synonyms | Low-density lipoprotein receptor, LDLR |
| Immunogen | Synthetic Peptide |
| Location | Golgi Apparatus, Lysosome, Endosome, Plasma Membrane |
| Accession | P01130 |
| Clone Number | SDT-057-57 |
| Antibody Type | Rabbit mAb |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Predicted Reactivity | Bv, Rb |
| Purification | Protein A |
| Concentration | 0.25mg/ml |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:1000 | |
| WB | 1:500 |
Background
The low density lipoprotein receptor (LDL R) is the founding member of the LDL R family of scavenger receptors.Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis.LDLR is ubiquitously expressed and is a key receptor for maintaining cholesterol homeostasis in mammals. LDLR-mediated endocytosis is essential for lipoprotein and lipid metabolism.Impaired LDLR function by genetic mutations results in a condition with extremely elevated serum LDL levels and early onset atherosclerosis known as familial hypercholesterolemia (FH).
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